![]() ![]() Ø Dermatan sulfate is derived from chondroitin by enzymatic epimerization of the C5 of glucuronate residues to form iduronate residues. Ø Dermatan sulfate is also in blood vessels, heart valves and lungs. Ø Dermatan sulfate is also called as chondroitin sulfate B. Ø There are different types of chondroitin sulfate in the cell based on the position of sulfate group(s). Ø It is also responsible for the high tensile strength of cartilage, tendon, ligaments and walls of the aorta. Ø In the cartilage, chondroitin sulfate provides resistance to compression. Ø Chondroitin sulfate is an important structural component of cartilage. ![]() Ø They have over 100 individual sugars, each of which can be sulfated in variable positions and quantities. Ø Usually, chondroitin sulfate is found attached to proteins as part of a proteoglycan. Ø It composed of alternating N-acetylgalactosamine and glucuronic acid. Ø Chondroitin sulfate is a sulfated glycosaminoglycan. Have one or more sulfate groups (hence having a negative charge). One or both monomeric units differ from those of hyaluronan. They are covalently linked to specific proteins (proteoglycans). They are generally much shorter polymers. Ø Other glycosaminoglycans differ from hyaluronan in FOUR aspects: Ø Human sperm cells produce hyaluronidase to hydrolyze the thick glycosaminoglycan coat of ovum ( Zona pellucida). Ø Many bacteria produce hyaluronidase enzyme(to enter into the host cell). Ø They are the essential components of cartilage. Ø They have high shock absorbing capacity, hence form the lubricants in synovial fluids (joints). Ø They serve as the vitreous humor of eye. Ø Hyaluronate form a clear highly viscous solution. ![]()
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